Related Experiment Video
Updated: Feb 22, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
Published on: May 21, 2017
Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening
1Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, London WC1E 6BT, UK. tom.treasure@gmail.com.
Abstract:
Personalised external aortic support was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. After putting together a research and development team, and finding a surgeon to take on the challenge to join him in this innovative approach, he was central to the manufacture of the device, custom made for his own aorta. He was the patient for the 'first in man' operation in 2004. Ten years later he is well and 45 other people have had their own personalised device implanted. In this account, the stepwise record of proof of principle, comparative quantification of the surgical and perioperative requirements, 10 years of results, and development and research plans for the future are presented.
Related Concept Videos
Aneurysm III: Interprofessional Care
Aortic Regurgitation III: Medical Management
Aneurysm I: Introduction

