Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

747
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
747

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left Atrial Dysfunction in End-Stage Kidney Disease: Improvement After Transplantation and Relation to Exercise Capacity.

Echocardiography (Mount Kisco, N.Y.)·2026
Same author

Abnormal Right Ventricular to Pulmonary Artery Coupling in Patients with End-Stage Kidney Disease and Normalization after Renal Transplantation: An Observational Study.

Nephron·2025
Same author

Corrigendum to "The positive effects of preoperative chlorhexidine rinse to reduce postoperative pneumonia after kidney transplantation surgery" [Surgeon. (2025) 23(1) 18-22].

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2025
Same author

Prevalence of left kidney vein entrapment signs on computed tomography angiography images of kidney donors.

Folia morphologica·2024
Same author

The positive effects of preoperative chlorhexidine rinse to reduce postoperative pneumonia after kidney transplantation surgery.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2024
Same author

Diagnostically challenging rupture of pancreaticoduodenal artery aneurysm: A case report.

Turkish journal of surgery·2023

Related Experiment Video

Updated: Feb 22, 2026

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

15.1K

Advances in small bowel transplantation.

Alp Gürkan1,2

  • 1Department of General Surgery, Çamlıca Medicana Hospital, İstanbul, Turkey.

Turkish Journal of Surgery
|September 26, 2017
PubMed
Summary

Small bowel transplantation faces challenges with graft rejection, a major cause of patient morbidity and mortality. New diagnostic methods are being explored to improve monitoring beyond traditional biopsies.

Keywords:
Small bowel transplantationintestinal transplantationshort bowel syndromesmall bowel insufiencystem cell transplantation

More Related Videos

Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

14.7K
Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

15.5K

Related Experiment Videos

Last Updated: Feb 22, 2026

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

15.1K
Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

14.7K
Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

15.5K

Area of Science:

  • Gastroenterology and Hepatology
  • Transplantation Immunology
  • Regenerative Medicine

Background:

  • Small bowel transplantation (SBT) is a critical treatment for intestinal failure, but graft rejection significantly impacts patient outcomes and graft survival.
  • Acute rejection affects 50%-75% of patients, while chronic rejection occurs in approximately 15%, highlighting the need for effective immune monitoring.

Purpose of the Study:

  • To review the current challenges in monitoring small bowel transplant recipients for graft rejection.
  • To discuss the limitations of traditional diagnostic methods, primarily protocol biopsies.
  • To explore emerging auxiliary assays and future directions for improved rejection detection.

Main Methods:

  • Review of existing literature on small bowel transplantation, graft rejection, and diagnostic techniques.
  • Analysis of the diagnostic accuracy and complications associated with histopathological examinations (biopsies).
  • Examination of novel auxiliary assays including blood markers (citrulline, calprotectin), immune cell analysis, cytokine profiling, and gene expression analysis.

Main Results:

  • Histopathological examination via protocol biopsies is the current gold standard but is invasive, carries complications, and can be non-diagnostic, necessitating multiple biopsies.
  • There is a lack of non-invasive and reliable markers for predicting rejection in small bowel transplantation, unlike other transplant types.
  • Auxiliary assays show promise in complementing biopsy findings and potentially offering less invasive monitoring strategies.

Conclusions:

  • Effective immune monitoring is crucial for small bowel transplant recipients due to high rates of rejection.
  • Current reliance on invasive biopsies presents limitations, driving the need for alternative and supplementary diagnostic tools.
  • Emerging techniques, including molecular and cellular assays, alongside advancements in tissue engineering and stem cell therapy, offer promising future avenues for improving SBT outcomes.