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Course of sepsis in rats with thyroid dysfunction.

Halil İbrahim Taşcı1, Mehmet Erikoğlu2, Hatice Toy3

  • 1Department of General Surgery, Reyhanli Public Hospital, Hatay, Turkey.

Turkish Journal of Surgery
|September 26, 2017
PubMed
Summary

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Thyroid dysfunction impacts sepsis progression. Hyperthyroidism mitigated sepsis severity in rats, while hypothyroidism worsened it, suggesting altered treatment strategies may be needed for sepsis patients with thyroid issues.

Area of Science:

  • Endocrinology
  • Sepsis Pathophysiology
  • Animal Models

Background:

  • Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection.
  • Thyroid hormones play a crucial role in regulating metabolism and cellular function, influencing the body's response to stress and infection.
  • Existing research primarily focuses on post-sepsis thyroid hormone changes, with limited investigation into the impact of pre-existing thyroid dysfunction on sepsis progression.

Purpose of the Study:

  • To investigate the influence of pre-existing thyroid dysfunction (hyperthyroidism and hypothyroidism) on the progression of sepsis.
  • To compare sepsis severity and organ damage in rats with induced hyperthyroidism and hypothyroidism versus control groups.

Main Methods:

  • Four groups of female Wistar albino rats were used: Sham, Sepsis Control, Hyperthyroidism-Sepsis, and Hypothyroidism-Sepsis.
Keywords:
Hyperthyroidismhypothyroidismorgan dysfunctionsepsis

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  • Sepsis was induced in relevant groups after establishing hyperthyroid or hypothyroid states.
  • Tissue and blood samples were collected 24 hours post-sepsis induction for analysis.

    • Main Results:

    • Sepsis progression and organ dysfunction (liver, lungs, kidneys) were significantly milder in the hyperthyroidism-sepsis group compared to control and hypothyroidism-sepsis groups.
    • Histopathological organ damage and laboratory parameters indicated less severe sepsis in hyperthyroid rats.
    • The hypothyroidism-sepsis group exhibited the most severe sepsis progression.

    Conclusions:

    • Pre-existing hyperthyroidism appears to have a protective effect against sepsis progression, while hypothyroidism exacerbates it.
    • Current treatment strategies for thyroid dysfunction in sepsis patients may require re-evaluation.
    • Further research with larger sample sizes is needed to confirm these findings and inform clinical practice regarding sepsis management in patients with thyroid disorders.