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Search for a gene that predisposes individuals to BPI disorder
D S Gerhard1, J A Egeland, D L Pauls
1Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Journal of Psychiatric Research
|January 1, 1987
Abstract:
To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnoses and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.