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Adjuvant treatments for ependymomas.

Emmett A Sartor1, Patrick Y Wen2,3,4

  • 1Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.

Journal of Neurosurgical Sciences
|September 26, 2017
PubMed
Summary

Ependymoma adjuvant therapy remains challenging, with surgery and radiation as primary treatments. Chemotherapy and targeted agents are explored for specific scenarios in children and adults with central nervous system tumors.

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Area of Science:

  • Neuro-oncology
  • Pediatric Oncology
  • Central Nervous System Tumors

Background:

  • Ependymomas are rare primary central nervous system tumors affecting children and young adults.
  • Tumor behavior ranges from indolent to locally aggressive, influenced by location, histology, and resection extent.

Purpose of the Study:

  • This review discusses current adjuvant therapy strategies for ependymomas in pediatric and adult populations.
  • It examines the role of chemotherapy and targeted agents in ependymoma treatment.

Main Methods:

  • The review synthesizes existing literature on ependymoma adjuvant therapy.
  • It analyzes treatment approaches based on patient age, disease characteristics, and treatment setting.

Main Results:

  • Maximal surgical resection and focal radiation therapy are mainstays of ependymoma treatment.
  • Chemotherapy, primarily cisplatin-based, is considered for residual disease or salvage therapy.
  • Chemotherapy may be used in young children to delay radiation or aid resection.
  • Targeted agents like bevacizumab and lapatinib are under investigation for recurrent disease, not adjuvant therapy.

Conclusions:

  • Adjuvant therapy for ependymomas is complex and individualized.
  • Established roles for chemotherapy and targeted agents in adjuvant settings are limited, with ongoing research for recurrent disease.