Related Experiment Video
Updated: Feb 22, 2026
A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Streptococcus agalactiae: prevention and vaccine development
A Puertas-Prieto, A Lara-Oya, C Liébana Martos
1Javier Rodríguez Granger, Servicio de Microbiología. Hospital Universitario Virgen de las Nieves. Avenida de las Fuerzas Armadas s/n C.P 18014 Granada, Spain. javierm.rodriguez.sspa@juntadeandalucia.es.
Insights
Group B Streptococcus (GBS) causes significant newborn and adult infections. Vaccination against GBS offers a promising strategy to prevent disease, especially when other methods are insufficient.
Area of Science:
- Microbiology
- Immunology
- Vaccinology
Background:
- Group B Streptococcus (GBS) is a leading cause of mortality and morbidity in newborns.
- GBS also poses a significant threat to immunocompromised adult populations.
- Current prevention strategies, including intrapartum prophylaxis, have limitations.
Purpose of the Study:
- To review current efforts in controlling GBS infections.
- To summarize the state-of-the-art in GBS vaccine development.
- To highlight diverse vaccine design strategies.
Main Methods:
- Literature review of GBS control measures.
- Analysis of current vaccine development strategies for GBS.
- Synthesis of data on GBS pathogenesis and prevention.
Main Results:
- Despite advances, GBS infections remain a challenge.
- Vaccination presents a potential solution for GBS prevention in neonates and adults.
- Various vaccine design approaches are being explored.
Conclusions:
- GBS vaccination is a critical area for future prevention efforts.
- Further research into novel vaccine strategies is warranted.
- Vaccines could complement existing GBS prevention measures.
Abstract:
Streptococcus agalactiae, group B Streptococcus (SGB), is the most important cause of morbi-mortality among newborn population, and an important pathogen among immunossupressed adult patients. Despite the advances in the treatment and prevention of neonatal infections as a consequence of implementation of national and international recommendations for prevention of infection, there are still some improvements for the final control of the disease. In this sense, the vaccination against SGB could be an effective measure for the prevention of disease in those cases where intrapartum prophylaxis is not useful and in adult patients with risk factors for invasive infection due to SGB. This review summarizes the efforts made until now in order to establish the control of the infection, and brings some information on the current state-of-the art of vaccines against SGB, in which different strategies in their design have been used.
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