Related Experiment Video
Updated: Feb 22, 2026
Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer
Published on: February 23, 2024
Orientation of Preclinical Research in Ovarian Cancer
Thaïs Baert1, Abhishek D Garg, Patrizia Agostinis
1*Department of Gynaecology and Obstetrics, Leuven Cancer Institute, University Hospitals Leuven; and †Department of Oncology, Laboratory for Tumor Immunology and Immunotherapy, ImmunOvar Research Group, ‡Department of Cellular and Molecular Medicine, Laboratory for Cell Death Research and Therapy, and §Department of Oncology, Laboratory of Gynaecological Oncology, KU Leuven, Leuven, Belgium.
Objectives:
A large variety of mouse models for cancer exist, also in the field of ovarian cancer. Each model possesses different features, which makes it difficult to interpret their translational value. This review provides an overview of the available ovarian cancer mouse models and their possible use in search for new treatments.
Methods:
This was a PubMed search of available literature on genetically engineered mouse models, xenografts, transplantable models, and immunocompetent mouse models in ovarian cancer, with a specific focus on clinically relevant features of the described models.
Results/Conclusions:
Several preclinical models are available for ovarian cancer. Based on their properties, a model should be carefully selected as a function of the experimental setup to achieve clinically relevant results.
