Copper-Mediated Introduction of the CF₂ PO(OEt)₂ Motif: Scope and Limitations

Herein, a general procedure to access CF₂ PO(OEt)₂ -containing molecules is reported. The reagent CuCF₂ PO(OEt)₂ is accessible by a simple protocol and a broad range of substrates can be functionalised. The procedure allows the conversion of aryl diazonium salts, as well as aryl, heteroaryl, vinyl and alkynyl iodonium salts, into the corresponding fluorinated molecules at room temperature. Mechanistic studies were performed to gain a better understanding of the reaction pathway. Under similar conditions, vinyl and aryl iodides, allyl halides, and benzyl bromides were also functionalised, and the scope and limitations of the reaction were studied. Finally, the procedure was extended to disulfides to offer new access to SCF₂ PO(OEt)₂ -containing molecules.