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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

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Asparaginase Toxicities: Identification and Management in Patients With Acute Lymphoblastic Leukemia


Van Thu Huynh1, Sharon Bergeron1

  • 1Children's Hospital of Orange County.

Clinical Journal of Oncology Nursing
|September 26, 2017
PubMed

Insights

Prompt identification and management of asparaginase toxicities are crucial for improving outcomes in acute lymphoblastic leukemia (ALL) treatment. This review details common side effects and management strategies for enhanced patient care.

Area of Science:

  • Oncology
  • Hematology
  • Pharmacology

Background:

  • Acute lymphoblastic leukemia (ALL) is a prevalent childhood cancer with improved outcomes due to intensified chemotherapy, including asparaginase.
  • Asparaginase is a key component in pediatric ALL treatment and is increasingly used in adults.

Purpose of the Study:

  • To provide an overview of asparaginase-associated toxicities.
  • To offer recommendations for managing these toxicities in clinical practice.

Main Methods:

  • A literature review was conducted.
  • The review focused on asparaginase and its common toxicities, including hypersensitivity, pancreatitis, thrombosis, hyperbilirubinemia, and hyperglycemia.

Main Results:

  • Rapid identification and management of asparaginase-associated adverse events are essential.
  • Effective management can reduce symptom severity and limit treatment interruptions, potentially improving patient outcomes.

Conclusions:

  • Timely intervention for asparaginase toxicities is critical for maintaining treatment continuity.
  • Understanding and managing these adverse events can lead to better therapeutic results in ALL patients.
Abstract

Keywords:
acute lymphoblastic leukemiaasparaginasehypersensitivitytoxicities

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