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Phencyclidine depresses transmitter release at the neuromuscular synapse of the locust
M E Kornhuber1, C Walther, J Kornhuber
1Department of Neurology, University of Ulm, F.R.G.
Neuroscience Letters
|December 16, 1987
Abstract:
The presynaptic effects of phencyclidine (PCP) were studied in the locust extensor tibiae muscle. The neurally evoked transmitter release is diminished in the presence of 5 x 10(-6) to 5 x 10(-5) M PCP. This is indicated (1) by an increased coefficient of variation of the excitatory junction potentials; (2) by an increased rate of failures (a) with nerve stimulation in low [Ca2+]saline and (b) with focal extracellular stimulation in normal [Ca2+]saline. The rate of spontaneous transmitter release is not affected.