Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives01:35

Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives

2.7K
Just like β-keto acids—which upon thermal decarboxylation form ketones—β-dicarboxylic acids undergo decarboxylation to generate monocarboxylic acids with the liberation of carbon dioxide.
2.7K
Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

4.2K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
4.2K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.4K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.4K
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization01:13

Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization

3.4K
Dieckmann cyclization is an intramolecular Claisen condensation of diesters. The reaction occurs in the presence of a base and generates a cyclic β-ketoester as the final product. Commonly, 1, 6 and 1, 7-diesters are preferred substrates for the reaction since the generated five, and six-membered cyclic β-keto esters are particularly more stable.
3.4K
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

2.4K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
2.4K
Oligosaccharide Assembly01:24

Oligosaccharide Assembly

3.7K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASO Visual Abstract: Consensus Guidelines on Perioperative Care in Primary Retroperitoneal Sarcoma Surgery.

Annals of surgical oncology·2026
Same author

Metabolic regulation of histone acetylation by ACLY supports MDR1 expression in colorectal cancer and highlights a targetable vulnerability.

Neoplasia (New York, N.Y.)·2026
Same author

Consensus Guidelines on Perioperative Care in Primary Retroperitoneal Sarcoma Surgery.

Annals of surgical oncology·2026
Same author

Physicochemical and Computational Study of the Encapsulation of Resv-4'-LA and Resv-4'-DHA Lipophenols by Natural and HP-β-CDs.

International journal of molecular sciences·2025
Same author

The Hormetic Adaptative Capacity and Resilience to Oxidative Stress Is Strengthened by Exposome Enrichment with Air Cold Atmospheric Plasma: A Metabolome Targeted Follow-Up Approach.

Biomedicines·2025
Same author

Discovery of novel acetylcholinesterase inhibitors through AI-powered structure prediction and high-performance computing-enhanced virtual screening.

RSC advances·2025

Related Experiment Video

Updated: Feb 22, 2026

Sequencing of Plant Wall Heteroxylans Using Enzymic, Chemical Methylation and Physical Mass Spectrometry, Nuclear Magnetic Resonance Techniques
11:49

Sequencing of Plant Wall Heteroxylans Using Enzymic, Chemical Methylation and Physical Mass Spectrometry, Nuclear Magnetic Resonance Techniques

Published on: March 24, 2016

8.1K

Complexation between oleanolic and maslinic acids with native and modified cyclodextrins.

Santiago López-Miranda1, Lucía Guardiola1, Pilar Hernández-Sánchez1

  • 1Department of Food Technology & Nutrition, UCAM Universidad Católica de Murcia, Avenida de los Jerónimos s/n, 30107 Guadalupe, Murcia, Spain.

Food Chemistry
|September 27, 2017
PubMed
Summary
This summary is machine-generated.

Complexing natural triterpenoids oleanolic acid (OA) and maslinic acid (MA) with cyclodextrins improved their solubility. This enhances their potential use in food and pharmaceuticals.

Keywords:
ComplexationComplexation constantCyclodextrinEfficiencyMaslinic acidOleanolic acidThermodynamic parameters

More Related Videos

Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry
08:51

Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry

Published on: June 20, 2025

693
OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides
08:43

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

Published on: June 20, 2010

14.2K

Related Experiment Videos

Last Updated: Feb 22, 2026

Sequencing of Plant Wall Heteroxylans Using Enzymic, Chemical Methylation and Physical Mass Spectrometry, Nuclear Magnetic Resonance Techniques
11:49

Sequencing of Plant Wall Heteroxylans Using Enzymic, Chemical Methylation and Physical Mass Spectrometry, Nuclear Magnetic Resonance Techniques

Published on: March 24, 2016

8.1K
Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry
08:51

Profiling of Permethylated Mucin O-glycans Using Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry

Published on: June 20, 2025

693
OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides
08:43

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

Published on: June 20, 2010

14.2K

Area of Science:

  • Natural Products Chemistry
  • Supramolecular Chemistry
  • Pharmaceutical Sciences

Background:

  • Oleanolic acid (OA) and maslinic acid (MA) are bioactive triterpenoids with health benefits.
  • Low solubility and permeability limit the application of OA and MA in food and pharmaceuticals.
  • Cyclodextrins (CDs) are widely used to improve the physicochemical properties of poorly soluble compounds.

Purpose of the Study:

  • To investigate the complexation of OA and MA with various cyclodextrins (α-, β-, γ-, HP-α-, HP-β-, HP-γ-CDs).
  • To evaluate the effect of pH and temperature on the complexation efficiency and stability.
  • To determine the feasibility of using cyclodextrin complexation for enhancing OA and MA bioavailability.

Main Methods:

  • Solubility diagrams were determined for OA and MA complexation with different CDs.
  • The influence of pH and temperature on complexation was systematically studied.
  • Phase solubility studies were conducted to characterize the inclusion complexes formed.

Main Results:

  • α- and HP-α-CDs did not form inclusion complexes with OA and MA.
  • β-, HP-β-, and HP-γ-CDs formed AL type complexes, while γ-CDs formed BS type complexes.
  • Complexation was more stable for MA but more efficient for OA; higher pH and temperature improved complexation.

Conclusions:

  • Specific cyclodextrins (β-, HP-β-, HP-γ-, γ-CDs) can form inclusion complexes with OA and MA.
  • Optimizing pH and temperature can enhance the complexation process, improving solubility.
  • This complexation strategy holds promise for the pharmaceutical and food industries to utilize OA and MA effectively.