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Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids

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A first step towards a consensus static in vitro model for simulating full-term infant digestion.

O Ménard¹, C Bourlieu¹, S C De Oliveira¹

¹STLO, UMR 1253, INRA, Agrocampus Ouest, Rennes, France.

|September 27, 2017

Summary

A new in vitro model simulates infant digestion, offering greater physiological relevance than existing methods. This tool aids scientists and manufacturers in studying infant formula digestion and structural evolution.

Keywords:

Digestion Infant Infant formula Model Static

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Area of Science:

Gastroenterology
Food Science
Biotechnology

Background:

In vitro models are crucial for studying food digestion, but few accurately simulate infant physiology.
Existing infant digestion models lack sufficient physiological relevance for accurate research.

Purpose of the Study:

To develop a physiologically relevant in vitro static gastrointestinal model for 28-day-old infants.
To compare infant formula digestion kinetics and structural changes using the new infant model versus an adult model.

Main Methods:

Extensive literature review of in vivo infant digestive conditions.
Development of a static in vitro gastrointestinal model tailored for infant physiology.
Application of the model to a commercial infant formula and comparison with adult digestion protocols.

Main Results:

The infant digestion model demonstrated different proteolysis and lipolysis kinetics compared to the adult model.
Key physiological differences, including lower enzyme/bile salt concentrations and higher gastric pH, influenced digestion outcomes.
Structural evolution of the infant formula during digestion was also analyzed.

Conclusions:

The developed in vitro static model provides a physiologically relevant simulation of infant digestion.
This model is valuable for scientists, food manufacturers, and pharmaceutical companies studying infant nutrition and product development.