Related Experiment Video

Updated: Feb 22, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.3K

Injury mechanisms in acute intracerebral hemorrhage

D Andrew Wilkinson1, Aditya S Pandey1, B Gregory Thompson1

  • 1Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.

Neuropharmacology
|September 27, 2017
PubMed

Insights

Intracerebral hemorrhage (ICH) remains a leading cause of death, with high mortality despite ongoing research. Current trials focus on minimally invasive clot removal and new drugs to improve recovery from brain bleeds.

Area of Science:

  • Neurology
  • Neurosurgery
  • Stroke Medicine

Background:

  • Intracerebral hemorrhage (ICH) is the most frequent type of hemorrhagic stroke.
  • ICH incidence is rising due to an aging global population.
  • Despite extensive research, ICH mortality rates remain high, with no proven interventional therapies.

Purpose of the Study:

  • To review current knowledge on ICH injury mechanisms.
  • To discuss recent clinical trial outcomes for ICH.
  • To explore novel signaling pathways for hematoma clearance.

Main Methods:

  • Literature review of ICH mechanisms and injury.
  • Analysis of recent clinical trial data for ICH therapies.
  • Examination of emerging signaling pathways in hematoma resolution.

Main Results:

  • No interventional therapy has yet improved ICH outcomes.
  • Ongoing clinical trials are evaluating minimally invasive clot removal.
  • Pharmacologic strategies for post-ICH recovery are under investigation.

Conclusions:

  • Minimally invasive clot removal shows promise for ICH treatment.
  • Pharmacologic interventions may enhance recovery after ICH.
  • Further research into signaling pathways is crucial for developing effective therapies.

Keywords:
Brain edemaHematomaHypertensionIntracerebral hemorrhageIronThrombin

More Related Videos

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.9K
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage09:41

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Published on: July 3, 2014

15.5K

Related Concept Videos

Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
13.8K
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
15.1K