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Updated: Aug 13, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Sulfasalazine-induced lupus erythematosus
1Department of Family Practice, University of Illinois College of Medicine, Peoria 61614.
The American Journal of Medicine
|March 1, 1988
Summary
Sulfasalazine therapy for ulcerative colitis can cause drug-induced lupus, presenting as lung inflammation and fluid around the heart. Symptoms resolved after stopping the medication and using corticosteroids.
Area of Science:
- Rheumatology
- Pulmonology
- Gastroenterology
Background:
- Sulfasalazine is a common treatment for inflammatory bowel disease.
- Drug-induced lupus is a potential adverse effect of various medications.
Observation:
- A 43-year-old male on long-term sulfasalazine for ulcerative colitis developed pneumonitis, bilateral pleural effusions, and cardiac tamponade.
- The patient also exhibited positive autoantibodies.
Findings:
- The patient's symptoms resolved within 4-6 months after discontinuing sulfasalazine and completing a corticosteroid course.
- This presentation suggests a case of sulfasalazine-induced lupus with serositis and pulmonary involvement.
Implications:
- Physicians should consider sulfasalazine-induced lupus in patients with inflammatory bowel disease presenting with unexplained serositis or pulmonary symptoms.
- Early recognition and management, including drug cessation and corticosteroid treatment, are crucial for favorable outcomes.
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