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MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
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Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition
Christiaan Hendrik Bas van Niftrik1,2, Marco Piccirelli2,3, Oliver Bozinov1,2
1Department of Neurosurgery University Hospital Zurich University of Zurich Zurich Switzerland.
Brain and Behavior
|September 27, 2017
Summary
This study introduces an iterative analysis to enhance cerebrovascular reactivity (CVR) measurements by decomposing the dynamic carbon dioxide- Blood Oxygen-Level Dependent (CO2-BOLD) relationship, improving CO2 arrival time accuracy.
Area of Science:
- Neuroimaging
- Physiology
- Medical Physics
Background:
- Quantitative cerebrovascular reactivity (CVR) measurements are crucial for assessing brain health.
- Current methods for dynamic CO2-BOLD analysis have limitations in temporal component decomposition.
Purpose of the Study:
- To develop and validate an iterative analysis for improved quantitative CVR measurements.
- To enhance the accuracy of CO2 arrival time estimations in dynamic CO2-BOLD relationships.
Main Methods:
- An iterative analysis was developed to decompose temporal components of the CO2-BOLD relationship.
- Redefined CO2 arrival time and separated vascular responses (DTP, DTB).
- Used 25 normal BOLD MRI datasets with CO2 challenges to create reference atlases.
Main Results:
- The redefined CO2 arrival time provided the best data fit.
- Excluding dynamic BOLD phases (DTP, DTB) yielded a static CVR based on plateau calibration.
- Demonstrated application in subjects with carotid artery occlusion.
Conclusions:
- Decomposition and iterative modeling of CO2-BOLD temporal components significantly improve quantitative CVR measurements.
- The novel approach offers enhanced accuracy for CVR assessment and CO2 transit time analysis.
