Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

41.8K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
41.8K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

750
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
750
What is Cell Signaling?02:03

What is Cell Signaling?

131.4K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.4K
Autocrine Signaling01:01

Autocrine Signaling

52.4K
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
52.4K
Overview of Cell Signaling01:23

Overview of Cell Signaling

25.3K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
25.3K
Coordination of Gene Expression Processes in Bacteria01:29

Coordination of Gene Expression Processes in Bacteria

732
The DNA replication, transcription, and translation processes are intricately coupled in bacteria, allowing efficient gene expression and rapid protein synthesis. While this physical and functional coordination is advantageous, it introduces challenges that bacteria overcome through specific regulatory mechanisms.Coupling of Replication, Transcription, and TranslationThe coupling of replication, transcription, and translation is a hallmark of bacterial gene expression. As the replisome unwinds...
732

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MALDI Tandem Mass Spectrometry for Colony-Based Dereplication of Natural Products.

bioRxiv : the preprint server for biology·2026
Same author

A high-throughput biocatalytic platform for screening isomeric kainoid natural products.

Cell reports. Physical science·2026
Same author

Tensile expansion microscopy applies mechanical force to super-resolve fixed and image live cellular samples.

bioRxiv : the preprint server for biology·2026
Same author

MALDI-FISH for Colocalization of Brominated Metabolites and <i>Pseudovibrio</i> spp. in <i>Aplysina</i> Tissue.

Journal of natural products·2026
Same author

Integrated Metabolomic and Genomic Insights into Amino Acid Incorporation Within the Hybrid Polyketide-Alkaloid Antibiotic TLN-05220.

ACS chemical biology·2026
Same author

Spatial metabolomics reveals the role of penicillic acid in cheese-rind microbiome disruption by a spoilage fungus.

mSystems·2026

Related Experiment Video

Updated: Feb 22, 2026

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.8K

Calling all hosts: Bacterial communication in situ.

Jessica L Cleary1, Alanna R Condren1, Katherine E Zink1

  • 1Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago IL 60612, USA.

Chem
|September 27, 2017
PubMed
Summary

Bacterial small molecules are key to host health, influencing pathogenic, symbiotic, and transient roles. Understanding these molecules is crucial for deciphering host-microbe associations and maintaining biological equilibrium.

Keywords:
Pathogenanalytical techniquesbacteriamass spectrometryspecialized metabolitestructure elucidationsymbionttransient

More Related Videos

In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria
05:52

In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria

Published on: June 28, 2018

12.3K
Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions
08:33

Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions

Published on: August 5, 2020

7.6K

Related Experiment Videos

Last Updated: Feb 22, 2026

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
09:49

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

Published on: November 18, 2022

2.8K
In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria
05:52

In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria

Published on: June 28, 2018

12.3K
Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions
08:33

Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions

Published on: August 5, 2020

7.6K

Area of Science:

  • Microbiology
  • Host-Microbe Interactions
  • Chemical Biology

Background:

  • Bacteria play diverse roles in host health, impacting equilibrium.
  • Bacterial small molecules are increasingly recognized for their influence on host homeostasis and dysbiosis.
  • Understanding these molecular mechanisms is vital for advancing biological and medical sciences.

Purpose of the Study:

  • To review the roles of bacterial small molecules in pathogenic, symbiotic, and transient host interactions.
  • To explore how these molecules contribute to host homeostasis or dysbiosis.
  • To discuss analytical techniques for studying bacterial small molecules in situ.

Main Methods:

  • Literature review of bacterial roles and small molecule functions.
  • Analysis of molecular communication in pathogenic, symbiotic, and transient bacterial states.
  • Discussion of analytical techniques for in situ small molecule research.

Main Results:

  • Pathogenic bacteria use small molecules for communication, colonization, immune evasion, virulence, and fitness.
  • Symbiotic bacteria utilize small molecules for acquisition, colonization, and maintenance, often leading to coevolution.
  • Transient bacteria produce small molecules offering immune and nutritional benefits to the host.

Conclusions:

  • Bacterial small molecules are central to host-microbe associations.
  • Further research into the function and identity of bacterial small molecules is essential.
  • A deeper understanding of these molecules will enhance our knowledge of host-microbe interactions and health.