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Related Experiment Video

Updated: Jun 28, 2026

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence
09:21

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Published on: October 11, 2018

Experimentally induced necrotic enteritis in chickens.

B S Cowen1, L D Schwartz, R A Wilson

  • 1Department of Veterinary Science, College of Agriculture, Pennsylvania State University, University Park 16802.

Avian Diseases
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

Necrotic enteritis was experimentally induced in broiler chickens, with an observed incidence of 1.3-10%. This range was lower than previously reported, and Clostridium perfringens was inconsistently isolated.

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Area of Science:

  • Animal Science
  • Veterinary Medicine
  • Microbiology

Background:

  • Necrotic enteritis is a significant enteric disease in broiler chickens.
  • Previous studies reported a wide incidence range of necrotic enteritis.

Purpose of the Study:

  • To experimentally induce necrotic enteritis in broiler chickens.
  • To compare the observed incidence with literature values.
  • To investigate the isolation of Clostridium perfringens.

Main Methods:

  • Broiler-type chickens were used in five experimental trials.
  • Necrotic enteritis was induced through specific dosing protocols.
  • Chickens were monitored for disease incidence.
  • Clostridium perfringens was isolated from liver and intestinal samples.

Main Results:

  • Necrotic enteritis was successfully produced in three of five trials.
  • The observed incidence ranged from 1.3% to 10%.
  • This incidence was lower and narrower than previously reported ranges (5.6-37.3%).
  • Clostridium perfringens was inconsistently isolated from dosed chickens.

Conclusions:

  • Experimental induction of necrotic enteritis in broiler chickens is achievable.
  • The incidence rate in this study was lower than previously documented.
  • Inconsistent Clostridium perfringens isolation suggests complexity in disease pathogenesis or detection.