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Updated: Feb 22, 2026
10:57
Synthesis and Performance Characterizations of Transition Metal Single Atom Catalyst for Electrochemical CO2 Reduction
Published on: April 10, 2018
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Nonmetallic carbon monoxide releasing molecules (CORMs)
Nawodi Abeyrathna1, Kenyatta Washington, Christopher Bashur
1Department of Chemistry, Florida Institute of Technology, Melbourne, FL 32901, USA. yliao@fit.edu.
Organic & Biomolecular Chemistry
|September 27, 2017
Summary
Nonmetallic carbon monoxide (CO)-releasing molecules (CORMs) offer low toxicity and tunable properties. This review details their synthesis, mechanisms, and biological applications, covering both light-independent and light-activated CORMs.
Area of Science:
- Chemistry
- Biochemistry
- Materials Science
Background:
- Carbon monoxide (CO) acts as a vital gasotransmitter regulating cellular functions.
- CO-releasing molecules (CORMs) enable controlled CO delivery for therapeutic applications.
- Nonmetallic CORMs are emerging as promising alternatives to metal-based compounds due to lower toxicity and easier modification.
Purpose of the Study:
- To review the synthesis, CO-release mechanisms, biological behaviors, and physicochemical properties of nonmetallic CORMs.
- To categorize nonmetallic CORMs based on their CO-release triggers (e.g., light-independent vs. light-dependent).
- To discuss future prospects and potential applications of these novel compounds.
Main Methods:
- Literature review of recent advancements in nonmetallic CORM research.
- Categorization of CORMs into light-independent and photo-activated (PhotoCORMs) groups.
- Analysis of synthetic strategies, release mechanisms, and biological evaluations.
Main Results:
- Nonmetallic CORMs encompass diverse structures, including methylene chloride, CORM-A1 derivatives, amine carboxyboranes, and bimolecular CORMs.
- PhotoCORMs include unsaturated cyclic diketones, xanthene carboxylic acids, meso-carboxy BODIPYs, and hydroxyflavones.
- These compounds demonstrate tunable properties and potential for various biological applications.
Conclusions:
- Nonmetallic CORMs represent a significant advancement in CO-delivery systems.
- Their low toxicity and versatility offer broad therapeutic and research potential.
- Further research into their development and application is warranted.
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