Interaction between gender and uric acid on hemoglobin A1c in community-dwelling persons
R Kawamoto1,2, D Ninomiya3,4, Y Kasai4
1Department of Community Medicine, Ehime University Graduate School of Medicine, Tōon, Ehime, 791-0295, Japan. rykawamo@m.ehime-u.ac.jp.
Insights
Serum uric acid (SUA) levels show gender-specific associations with glycated hemoglobin (HbA1c). These findings highlight the importance of considering gender in managing diabetes and cardiovascular risk factors.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Cardiovascular Health
Background:
- Elevated glycated hemoglobin (HbA1c) is a known risk factor for cardiovascular disease (CVD).
- Serum uric acid (SUA) levels are implicated in glucose intolerance and type 2 diabetes.
- The potential for gender-specific relationships between SUA and HbA1c remains unexplored.
Purpose of the Study:
- To investigate the association between serum uric acid (SUA) levels and glycated hemoglobin (HbA1c).
- To determine if gender influences the relationship between SUA and HbA1c in a community-dwelling population.
Main Methods:
- Recruited 1636 participants (696 men, 940 women) aged approximately 70 years for annual health examinations.
- Employed multiple linear regression analysis to assess associations between SUA, HbA1c, and other metabolic factors within each gender.
- Examined the interaction between gender and SUA as determinants of HbA1c.
Main Results:
- In men, SUA was negatively associated with HbA1c, while in women, SUA was positively associated with HbA1c.
- Antidiabetic medication use and estimated glomerular filtration rate (eGFR) were also significant predictors of HbA1c in men.
- Gender, SUA, antidiabetic medication use, and eGFR were significant independent determinants of HbA1c, with a notable interaction between gender and SUA, particularly in individuals not on antidiabetic medications.
Conclusions:
- A significant interaction exists between gender and serum uric acid (SUA) in relation to glycated hemoglobin (HbA1c).
- This gender-specific association is independent of other metabolic factors in community-dwelling individuals.
- Findings suggest tailored approaches considering gender may be beneficial for managing HbA1c.
Introduction:
Higher glycated hemoglobin (Hb) (HbA1c) is significantly associated with an increased risk of cardiovascular disease (CVD). Serum uric acid (SUA) levels are associated with glucose intolerance and type 2 diabetes. Whether gender-specific differences regarding the relationship between SUA levels and HbA1c exist is unknown.
Aim:
We recruited 1636 (men, 696 aged of 70 ± 10 years; women, 940 aged of 70 ± 9 years) participants and enrolled in the study during their annual health examination from a single community. We investigated the association between SUA levels and HbA1c within each gender.
Results:
Multiple linear regression analysis showed that in men, SUA (β = -0.091, p = 0.014) with prevalence of antidiabetic medication (β = 0.428, p < 0.001) and eGFR (β = 0.112, p = 0.016) were significantly and negatively associated with HbA1c, and in women, SUA (β = 0.101, p = 0.002) with prevalence of antidiabetic medication (β = 0.458, p < 0.001) were significantly and positively associated with HbA1c. Moreover, the interaction between gender and SUA (β = 0.445, p < 0.001) as well as gender (β = -0.465, p < 0.001), prevalence of antidiabetic medication (β = 0.444, p < 0.001), eGFRCKDEPI (β = 0.074, p = 0.014), and SUA (β = -0.356, p < 0.001) was a significant and independent determinant of HbA1c. A significant interactive effect of gender and SUA on determinants of HbA1c was noted in patients not on antidiabetic medications, regardless of age, HbA1c, and renal function.
Conclusions:
The interaction between gender and SUA was associated with HbA1c independent of other metabolic factors in community-dwelling persons.
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