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Analysis of pediatric adverse reactions to transfusions

Sarah Vossoughi1,2, Gabriela Perez3, Barbee I Whitaker3

  • 1Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, New York.

Transfusion
|September 27, 2017
PubMed

Insights

Pediatric patients experience twice the rate of blood transfusion reactions compared to adults, with higher risks for allergic and febrile reactions. Further research is needed to understand these differences in pediatric transfusion reactions.

Area of Science:

  • Hematology
  • Pediatric Medicine
  • Transfusion Medicine

Background:

  • Physiological and biochemical differences exist between pediatric and adult patients.
  • Lack of multi-institutional studies on transfusion reaction differences between age groups.
  • This study addresses adverse responses to blood transfusions in pediatric versus adult populations.

Purpose of the Study:

  • To characterize differences in the frequency, type, and severity of transfusion reactions between pediatric and adult patients.
  • To compare adverse transfusion event rates across different blood components.
  • To identify specific reaction types that occur more frequently in children.

Main Methods:

  • Retrospective data analysis from January 2009 to December 2015.
  • Inclusion of data from nine children's hospitals and 35 adult hospitals.
  • Reporting reaction rates per 100,000 transfusions for comparative analysis.

Main Results:

  • Pediatric patients exhibited a higher overall transfusion reaction rate (538 vs. 252 per 100,000).
  • Significantly higher rates of red blood cell and platelet transfusion reactions were observed in children.
  • Pediatric patients had increased rates of allergic, febrile nonhemolytic, and acute hemolytic reactions.

Conclusions:

  • Pediatric patients have double the rate of transfusion reactions compared to adults.
  • Observed pediatric reaction rates exceed national reported data, highlighting a critical gap.
  • Further investigation into pediatric transfusion reaction differences and practices is warranted.
Abstract

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