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An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
Published on: November 4, 2022
[Optimize excipients for Yinsang hypoglycemic granules by using multiple indexes].
Jun-Chao Du1,2, Jian-Ming Cheng1,2, Rui Liu1,2
1Jiangsu Key Laboratory of Research and Development in Marine Bio-resoure Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Optimal excipients were identified for Yinsang hypoglycemic granules to improve stability. The best formulation uses mulberry leaf paste, microcrystalline cellulose, and mactra veneriformis crude polysaccharides, enhancing hygroscopicity and liquefaction.
Area of Science:
- Pharmaceutical Sciences
- Pharmacognosy
Background:
- Herbal extracts often face challenges with hygroscopicity and poor physical properties.
- Yinsang granules, a hypoglycemic preparation, require optimized excipients for improved stability and efficacy.
Purpose of the Study:
- To screen and identify optimal excipients for Yinsang hypoglycemic granules.
- To evaluate the impact of excipients on granule properties like hygroscopicity, formability, and fluidity.
Main Methods:
- Single factor tests were conducted using hygroscopicity, formability, and fluidity as key indexes.
- Moisture content, granule yield, and angle of repose were analyzed to determine optimal excipient ratios.
- Critical relative humidity (CRH) of the selected Yinsang granules was measured.
Main Results:
- The optimal excipient combination was determined as mulberry leaf paste-microcrystalline cellulose-mactra veneriformis crude polysaccharides (10:9:1.67).
- The resulting Yinsang granules exhibited good formability and fluidity, with reduced moisture absorption and a CRH of 73%.
Conclusions:
- The developed formulation process is effective and suitable for industrial production of Yinsang granules.
- The optimized excipients significantly enhance the hygroscopicity and liquefaction properties, improving the overall stability of Yinsang granules.
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