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Updated: Feb 22, 2026

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
[Studies on alkaloids from Melodinus moraei]
Yan Lu1, Nai-Tao Shen1, He-Yong Yu1
1The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu 322000, China.
Abstract:
To study the alkaloids from Melodinus moraei,seven compounds were separated and purified by column chromatography over silica gel, reverse phase silica gel and preparative HPLC. Their chemical structures were elucidated by MS and spectral data (1H-NMR, 13C-NMR) as scandine(1),tabersonine(2),melodinine N(3),melodinine P(4), melodinine T(5),19-epimeloscandonine(6),16-hydroxy-19S-vindolinine(7). Compounds 1-7 were isolated from M. moraei for the first time.The bioassays showed all tested samples displayed antitumor activity against the cell lines such as A549,PC-3,HGC-27 and HL-60.
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