Related Experiment Video
Updated: Feb 22, 2026
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
3D echocardiographic evaluation of right ventricular function and strain: a prognostic study in paediatric pulmonary
Pei-Ni Jone1, Michal Schäfer1, Zhaoxing Pan2
1Pediatric Cardiology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, 13123 East 16th Avenue, B100, Aurora, CO, USA.
Insights
Children with pulmonary hypertension show impaired right ventricular function. Three-dimensional echocardiography measures like RV ejection fraction and fractional area change predict adverse outcomes in pediatric pulmonary hypertension.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Echocardiography
Background:
- Pulmonary hypertension (PH) in children leads to significant right ventricular (RV) dysfunction.
- Accurate assessment of RV function is crucial for prognosis in pediatric PH.
- Three-dimensional echocardiography (3DE) offers advanced RV volumetric and functional analysis.
Purpose of the Study:
- To compare RV functional indices derived from 3DE in children with PH versus healthy controls.
- To determine the predictive value of these 3DE-derived indices for clinical outcomes in pediatric PH.
Main Methods:
- Ninety-six pediatric PH patients and 40 controls underwent 3DE.
- Off-line analysis generated 3D end-diastolic volume, 3D end-systolic volume, 3D stroke volume, 3D RV ejection fraction (EF), RV longitudinal strain (LS) of free wall and septum, tricuspid annular plane systolic excursion (TAPSE), and fractional area change (FAC).
Main Results:
- Pediatric PH patients exhibited higher RV volumes and lower RV EF, RVLS (free wall and septum), TAPSE, and FAC compared to controls (P < 0.001).
- 3D RV EF, free wall RVLS, and FAC were significant predictors of adverse clinical outcomes (P < 0.001).
Conclusions:
- Pediatric PH is associated with impaired RV function compared to healthy children.
- 3DE-derived indices including RV EF, volumes, FAC, and free wall RV strain are valuable outcome predictors in pediatric PH.
Aims:
To evaluate right ventricular functional indices using 3D echocardiography (3DE) between normal children and paediatric pulmonary hypertension (PH) patients, and to evaluate these indices as outcome predictors in children with PH.
Methods And Results:
Ninety-six paediatric PH patients from 2014 to 2016 were compared with 40 normal controls. All patients underwent 3DE and off-line analysis generated 3D end-diastolic volume, 3D end-systolic volume, 3D stroke volume, 3D right ventricular (RV) ejection fraction (EF), RV longitudinal strain (LS) free wall and septum, tricuspid annular plane systolic excursion (TAPSE), and fractional area change (FAC). PH patients had higher RV volumes, lower RV EF, lower free wall and septal RVLS, lower TAPSE, and lower FAC compared with normal controls (all P < 0.001). 3D RV EF, free wall RVLS, and FAC are predictors of adverse clinical outcomes [hazard ratio (confidence interval) 0.1 (0.03-0.27], P < 0.001; 0.17 (0.07-0.45), P < 0.001; 0.08 (0.03-0.22); P < 0.001, respectively).
Conclusion:
Paediatric PH patients have impaired RV function compared with normal children. 3D RV EF, volumes, FAC, and free wall RV strain serve as outcome predictors for paediatric PH patients.
More Related Videos
10:33Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
Published on: February 3, 2014
10:03Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025