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Updated: Feb 22, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
Delayed prosthesis malposition after transcatheter aortic valve implantation causing coronaries obstruction
Francesco Nappi1, Cristiano Spadaccio2,3, Jean-Louis Sablayrolles4
1Department of Cardiac Surgery, Centre Cardiologique du Nord de Saint-Denis (CCN), Saint-Denis, Paris, France.
Insights
Delayed CoreValve malposition caused coronary obstruction. Cardiac-gated computed tomography identified fibrosis/calcification on the misplaced valve as the cause, aiding diagnosis and decision-making.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Transcatheter aortic valve replacement (TAVR) is a common procedure for aortic stenosis.
- Device malposition can lead to complications.
- Coronary ostial obstruction is a rare but serious complication after TAVR.
Observation:
- A case of delayed CoreValve malposition nine months post-implant.
- Patient presented with acute coronary syndrome due to ostial stenosis of left main and right coronary arteries.
- Paravalvular leakage was noted from the bioprosthesis.
Findings:
- Gated computed tomography (CT) revealed valve malposition with cusps 14 mm above the right coronary ostium.
- Fibrous and calcific agglomerations on a misplaced cusp caused tight left ostial stenosis.
- CT identified valve-related fibrosis/calcification as the trigger for coronary obstruction.
Implications:
- Cardiac-gated CT is crucial for diagnosing TAVR complications.
- This case highlights an unusual phenomenon of fibrosis/calcification causing coronary obstruction.
- Promoting cardiac-gated CT can improve diagnosis and clinical decision-making in TAVR patients.
Abstract:
A case of delayed malposition of a CoreValve device causing obstruction of coronary ostia is described. Nine months after the original implant, the patient developed an acute coronary syndrome and was readmitted to hospital. Angiogram demonstrated an ostial stenosis of both the left main stem and the right coronary ostia, which were filled by a paravalvular leakage of the bioprosthesis. Gated computed tomography scan with 3D reconstruction showed valve malposition with cusps situated 14 mm above the ostium of the right coronary and the presence of fibrous and calcific agglomerations associated to one of the cusp causing a tight stenosis of the left ostium. Computed tomography scan is a crucial imaging technique in the transcatheter aortic valve replacement field and in this case enabled us to identify an interesting phenomenon of fibrosis/calcification originating at the level of the misplaced valve, which was actually the triggering cause of the coronary obstruction. Considering the reported need for more accurate investigations regarding the predictors of negative outcomes and the selection of transcatheter aortic valve replacement candidates, the use of cardiac-gated computed tomography should be stimulated and promoted as a valuable aid for the diagnosis and further clinical decision making in those patients.
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