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The IL-4 rs2070874 polymorphism may be associated with the severity of recurrent viral-induced wheeze

Flore Amat1,2,3,4, Malek Louha5, Marta Benet4,6,7

  • 1Department of Allergology-Centre de l'Asthme et des Allergies, Hôpital d'Enfants Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.

Pediatric Pulmonology
|September 27, 2017
PubMed

Insights

Genetic variants in asthma candidate genes are linked to childhood wheezing phenotypes. The IL-4 rs2070874 polymorphism

Area of Science:

  • Pediatric Pulmonology
  • Genetics
  • Immunology

Background:

  • Childhood recurrent wheezing presents diverse phenotypes, often leading to asthma.
  • Identifying genetic links to these phenotypes is crucial for early diagnosis and management.

Purpose of the Study:

  • To investigate the association between genetic variants of asthma candidate genes and specific phenotypes of early-onset wheezing in children.
  • To explore the role of genetic polymorphisms in differentiating wheezing phenotypes.

Main Methods:

  • Recruited young children with recurrent wheezing, assessing wheezing severity, atopic comorbidities, and biomarkers.
  • Genotyped 16 single nucleotide polymorphisms (SNPs) associated with asthma or atopy.
  • Utilized hierarchical clustering for phenotype grouping and multinomial logistic regression for SNP association analysis.

Main Results:

  • Three distinct wheezing phenotypes were identified: nonatopic uncontrolled severe wheeze (n=207), atopic multiple trigger wheeze (n=61), and episodic viral wheeze (n=49).
  • The TT-genotype of the IL-4 rs2070874 polymorphism showed a significant association with the severe, nonatopic wheeze phenotype compared to episodic viral wheeze (OR 7.9; P=0.001).

Conclusions:

  • The IL-4 rs2070874 polymorphism's association with severe viral-induced wheeze highlights the role of IL-4 in inflammatory pathways.
  • This finding contributes to understanding the genetic underpinnings of severe wheezing phenotypes in children.
Abstract

Keywords:
IL-4 polymorphismasthma & early wheezebiomarkersearly onset wheezeepidemiologygeneticsnonatopic uncontrolled severe wheezephenotypers2070874viral-induced wheeze

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