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The Effects of Two Different Multivitamins on Aging Mice
Su-Xi Wu1, Xiao-Miao Han1, Xue-Wei Jiang1
1School of Chemistry and Bioengineering, Changsha University of Science and Technology, Changsha 410004, Hunan, People’s Republic of China.
The Chinese Journal of Physiology
|September 28, 2017
Summary
Two multivitamins showed significant anti-aging effects in mice, improving biochemical markers and reducing aging symptoms. Vitamins B₁, B₂, B₆, and PP were identified as key anti-aging nutrients.
Area of Science:
- Gerontology and Nutritional Science
- Biochemistry of Aging
Background:
- Investigating novel anti-aging strategies beyond antioxidants is crucial for theoretical and practical advancements.
- Aging is associated with detrimental biochemical changes in organs like the brain and liver.
Purpose of the Study:
- To evaluate the anti-aging efficacy of two distinct multivitamin formulations in a mouse model.
- To identify specific vitamins contributing to anti-aging effects.
Main Methods:
- D-galactose induced aging in 40 mice, divided into aging model, control, multivitamin-1, and multivitamin-2 groups.
- Biochemical markers of aging and anti-aging (malondialdehyde, monoamine oxidase, glutathione peroxidase, superoxide dismutase) were measured in brain and liver tissues.
- Statistical analysis was performed to determine significant differences between groups.
Main Results:
- Multivitamin administration significantly ameliorated aging symptoms in mice compared to the aging model group.
- Both multivitamins significantly reduced malondialdehyde (MDA) and monoamine oxidase (MAO) levels (P < 0.01).
- Activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) isomers (Cu/Zn-SOD, Mn-SOD) significantly increased (P < 0.01) with no significant difference between the two formulations.
Conclusions:
- Vitamins B₁, B₂, B₆, and PP (Nicotinic acid) are key anti-aging nutrients within the tested multivitamin formulations.
- These B vitamins demonstrate significant efficacy in combating aging processes at the biochemical level in mice.
- Multivitamins offer a promising nutritional approach to mitigating age-related decline.
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