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Dedifferentiated Liposarcoma Mimicking a Primary Colon Mass
Blake Hollowoa1, Laura W Lamps2, Jason S Mizell1
11 University of Arkansas for Medical Sciences, Little Rock, AR, USA.
International Journal of Surgical Pathology
|September 28, 2017
Summary
Dedifferentiated liposarcoma can rarely mimic primary colon cancer, presenting as an intestinal mass. This highlights the importance of considering liposarcoma in the differential diagnosis for gastrointestinal masses.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Dedifferentiated liposarcoma (DDLS) is a high-grade sarcoma originating from well-differentiated liposarcoma.
- It typically presents as a large retroperitoneal mass and rarely involves the gastrointestinal (GI) tract significantly.
Observation:
- A unique case of DDLS presented radiographically mimicking a primary colon mass, causing intussusception.
- Histopathologic analysis revealed a high-grade sarcoma invading the colon wall, with surrounding pericolonic adipose tissue composed of well-differentiated liposarcoma.
Findings:
- This case demonstrates that DDLS can uncommonly present as a primary intestinal mass, mimicking colon cancer.
- Radiographic findings of perigastrointestinal or retroperitoneal fatty masses with adjacent fat stranding should raise suspicion for this rare presentation.
Implications:
- Awareness of this unusual presentation is crucial for accurate radiologic differential diagnosis.
- Pathologists should include DDLS in the differential diagnosis for high-grade spindle cell tumors of the retroperitoneum and intra-abdominal visceral organs.
