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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
439
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

473
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
473
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

483
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

422
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Statins in Peripheral Arterial Disease.

Scott T Chiesa1, Nikos Papageorgiou1, Marietta Charakida1

  • 1Institute of Cardiovascular Science, University College London. United Kingdom.

Current Pharmaceutical Design
|September 28, 2017
PubMed
Summary
This summary is machine-generated.

Statins are underused in peripheral arterial disease (PAD) patients despite proven benefits. This review highlights statins' role in reducing cardiovascular events and improving symptoms in PAD, supporting guideline recommendations.

Keywords:
Arterial Disease

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Peripheral arterial disease (PAD) is a prevalent atherosclerotic condition impacting lower extremities.
  • PAD patients exhibit shared cardiovascular risk factors with coronary artery disease patients, leading to elevated morbidity and mortality.

Purpose of the Study:

  • To review evidence supporting the efficacy of statins in peripheral arterial disease (PAD) management.
  • To discuss the lipid-lowering and pleiotropic effects of statins in PAD.
  • To present current guidelines recommending statin use in PAD patients.

Main Methods:

  • Literature review of studies on statin use in peripheral arterial disease.
  • Analysis of data on cardiovascular events and symptom-related outcomes.
  • Discussion of lipid-lowering and pleiotropic mechanisms of statins.

Main Results:

  • Statins demonstrate a beneficial role in reducing cardiovascular events for PAD patients.
  • Statins improve symptom-related outcomes in individuals with PAD.
  • Pleiotropic effects of statins, beyond lipid reduction, contribute to their benefits.

Conclusions:

  • Statins are crucial for managing peripheral arterial disease (PAD) by reducing cardiovascular risks and improving symptoms.
  • Current guidelines strongly advocate for statin administration in PAD patients.
  • Further emphasis on statin use in PAD is warranted to improve patient outcomes.