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Lactobacillus iners, the unusual suspect.

Mario Vaneechoutte1

  • 1Laboratory of Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan 185, Medical Research Building 2, Ghent University Hospital, B-9000 Gent, Belgium.

Research in Microbiology
|September 28, 2017
PubMed
Summary
This summary is machine-generated.

Lactobacillus iners, an unusual bacterium, is frequently found in vaginal dysbiosis and offers limited protection against infections and adverse pregnancy outcomes. Research suggests it may contribute to dysbiosis and pose risks during pregnancy.

Keywords:
Adverse pregnancy outcomeInerolysinLactobacillus inersVaginal dysbiosis

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Area of Science:

  • Microbiology
  • Gynecology

Background:

  • Lactobacillus iners exhibits unique metabolic and growth characteristics, differing from other Lactobacillus species.
  • Its role in the vaginal microbiome is complex and not fully understood.

Purpose of the Study:

  • To investigate the ambiguous role of Lactobacillus iners in vaginal health.
  • To determine if L. iners contributes to vaginal dysbiosis and adverse pregnancy outcomes.

Main Methods:

  • Review of epidemiological studies on vaginal microbiome composition.
  • Analysis of L. iners's metabolic and cytotoxic properties.

Main Results:

  • L. iners does not grow on de Man Rogosa Sharpe agar and produces limited lactic acid and hydrogen peroxide.
  • This species produces the unusual cytotoxin, inerolysin.
  • High prevalence of L. iners is associated with vaginal dysbiosis, offering limited protection against infections and adverse pregnancy outcomes.

Conclusions:

  • Lactobacillus iners possesses unique characteristics that differentiate it from other lactobacilli.
  • The species is frequently detected in vaginal dysbiosis and may exacerbate the condition.
  • L. iners is implicated as a potential risk factor for adverse pregnancy outcomes.