Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer
Devesh Tewari1, Seyed Fazel Nabavi2, Seyed Mohammad Nabavi2
1Department of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital, 263 136, Uttarakhand, India.
Abstract:
Activator protein 1 (AP-1) is a key transcription factor in the control of several cellular processes responsible for cell survival proliferation and differentiation. Dysfunctional AP-1 expression and activity are involved in several severe diseases, especially inflammatory disorders and cancer. Therefore, targeting AP-1 has recently emerged as an attractive therapeutic strategy for cancer prevention and therapy. This review summarizes our current understanding of AP-1 biology and function as well as explores and discusses several natural bioactive compounds modulating AP-1-associated signaling pathways for cancer prevention and intervention. Current limitations, challenges, and future directions of research are also critically discussed.
Insights
Activator protein 1 (AP-1) is crucial for cell survival and proliferation. Targeting AP-1 with natural compounds offers a promising strategy for cancer prevention and therapy, despite existing challenges.
Area of Science:
- Molecular Biology
- Cellular Biology
- Oncology
Background:
- Activator protein 1 (AP-1) is a critical transcription factor regulating cell survival, proliferation, and differentiation.
- Aberrant AP-1 activity is implicated in severe diseases, particularly cancer and inflammatory disorders.
- Targeting AP-1 presents a viable therapeutic strategy for cancer intervention and prevention.
Purpose of the Study:
- To review the fundamental biology and function of AP-1.
- To explore natural bioactive compounds that modulate AP-1 signaling pathways.
- To discuss AP-1-targeted strategies for cancer prevention and therapy.
Main Methods:
- Literature review of AP-1 biology and function.
- Analysis of natural compounds affecting AP-1 signaling.
- Discussion of therapeutic potential and research challenges.
Main Results:
- AP-1 plays a central role in cellular processes linked to cancer development.
- Several natural compounds demonstrate potential in modulating AP-1 pathways.
- Targeting AP-1 is a developing area for cancer therapeutics.
Conclusions:
- Understanding AP-1's role is key to developing novel cancer therapies.
- Natural compounds offer a promising avenue for AP-1-targeted cancer intervention.
- Further research is needed to overcome limitations and advance AP-1-based strategies.
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