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Related Experiment Video

Updated: Feb 22, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
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Copper deficiency caused by excessive alcohol consumption.

Shunichi Shibazaki1, Shuhei Uchiyama2, Katsuji Tsuda3

  • 1Department of Emergency and General Internal Medicine, Hitachinaka General Hospital, Hitachinaka, Ibaraki, Japan.

BMJ Case Reports
|September 28, 2017
PubMed
Summary

Alcohol abuse can lead to copper deficiency, causing anemia and neurological issues. This case report highlights a patient whose symptoms improved with copper supplementation, suggesting alcohol abuse as a novel risk factor.

Keywords:
alcoholic liver diseasediethaematology (incl blood transfusion)peripheral nerve disease

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Area of Science:

  • Medicine
  • Neurology
  • Hematology

Background:

  • Copper deficiency is a treatable condition causing cytopaenia and neuropathy.
  • Known risk factors include long-term tube feeding, parenteral nutrition, intestinal resection, and zinc ingestion.
  • Alcohol abuse has not been previously recognized as a risk factor for copper deficiency.

Purpose of the Study:

  • To report a case of copper deficiency in a patient with a history of significant alcohol abuse.
  • To identify alcohol abuse as a potential, previously unrecognized risk factor for copper deficiency.

Main Methods:

  • A case study of a 71-year-old male patient presenting with symptoms suggestive of copper deficiency.
  • Diagnostic evaluation included blood tests to assess copper and ceruloplasmin levels, and complete blood count.
  • Treatment involved copper supplementation via cocoa, and monitoring of clinical and hematological parameters.

Main Results:

  • The patient presented with macrocytic anemia, low copper, and low ceruloplasmin levels.
  • No other known risk factors for copper deficiency were identified.
  • Following copper supplementation, the patient's anemia resolved, and mobility improved.

Conclusions:

  • This case suggests that chronic alcohol abuse may be a risk factor for developing copper deficiency.
  • Copper supplementation can effectively treat the hematological and neurological manifestations of copper deficiency.
  • Further research is warranted to elucidate the mechanisms linking alcohol abuse to copper deficiency.