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Related Experiment Video

Updated: Feb 22, 2026

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

Adaptation trajectories during adhesion and spreading affect future cell states.

Stéphanie M C Bruekers¹, Min Bao¹, José M A Hendriks¹

¹Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.

Scientific Reports

|September 28, 2017

Summary

Cell behavior adapts to new environments through dynamic changes. Initial cell spreading on different substrates influences future cell states, impacting gene expression and YAP/TAZ localization.

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Area of Science:

Cell biology
Biophysics
Systems biology

Background:

Cells dynamically adapt gene expression and protein interactions to environmental changes.
Cell seeding and spreading on substrates is a key adaptation process.
Initial cell organization during spreading may influence subsequent behavior.

Purpose of the Study:

To investigate how cell spreading dynamics on substrates with varying physical properties influence later cellular behavior.
To map distinct cellular response trajectories to different substrate conditions.

Main Methods:

Studied cell spreading dynamics on collagen- and fibrin-coated polyacrylamide gels and hydrogels.
Quantified cellular states using RNA expression levels, YAP/TAZ localization, proliferation, and differentiation propensities.

Main Results:

Cells exhibited distinct morphological change trajectories on different substrates.
Substrate-specific trajectories led to fundamentally different cell states.
Continuous cellular adaptation to environmental cues leaves lasting traces, complicating direct correlations between physical properties and cell phenotype.

Conclusions:

The physical properties of substrates significantly influence cell spreading dynamics and subsequent cell states.
Cellular adaptation is a complex process where initial responses leave persistent imprints on cell behavior.
Direct correlations between specific physical properties and cellular phenotypes are obscured by the adaptive nature of cells.