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Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?
Bengu Cevirgen Cemil1, Demet Yilmazer2, Hatice Atas1
1Department of Dermatology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Introduction:
Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis.
Aim:
To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP.
Material And Methods:
Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the disease and body surface area (BSA) covered by the lesions was recorded. Immunohistochemically, the expression of CRH-R1 was stained in the lesional skin of patients with LP and in the control group.
Results:
The comparison of CRH-R1 expression showed a statistically significant difference between LP patients and the controls (p < 0.05). Additionally, we did not observe any correlation between BSA and staining intensity in LP patients.
Conclusions:
Our study showed an increase in CRH-R1 expression in LP lesions. These results support the participation of the cutaneous CRH/CRH-R1 system in the pathogenesis of LP skin lesions.
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