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Selective cell transplantation using bioabsorbable artificial polymers as matrices.

J P Vacanti1, M A Morse, W M Saltzman

  • 1Department of Surgery, Children's Hospital, Boston, MA 02115.

Journal of Pediatric Surgery
|January 1, 1988
PubMed
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This study introduces a novel cell transplantation method, attaching cells to biodegradable polymers before implantation. This "chimeric neomorphogenesis" shows promise for hepatocyte and intestinal cell engraftment in animal models.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Cell Biology

Background:

  • Traditional cell transplantation involves injecting cell suspensions.
  • This method has limitations in cell survival and targeted delivery.

Purpose of the Study:

  • To develop and evaluate a novel method for cell transplantation using polymer scaffolds.
  • To assess the viability and engraftment of various cell types on biodegradable polymers.

Main Methods:

  • Cells (hepatocytes, intestinal, pancreatic islets) were cultured on biodegradable polymers (polyglactin 910, polyanhydrides, polyorthoester).
  • Cell-polymer scaffolds were implanted into recipient animals (omentum, fat pad, mesentery).
  • Engraftment, cell viability, proliferation, and vascularization were assessed.

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Main Results:

  • Cells remained viable and proliferated on scaffolds in culture.
  • Successful engraftment of fetal intestinal cells and hepatocytes (fetal and adult) was observed post-implantation.
  • Hepatocyte engraftments showed viability, mitotic figures, and vascularization.
  • Pancreatic islets did not survive implantation.

Conclusions:

  • Attaching cells to biodegradable polymer scaffolds is a viable alternative for cell transplantation.
  • "Chimeric neomorphogenesis" shows potential for regenerative medicine applications, particularly for hepatocytes and intestinal cells.
  • Further research is needed to optimize this technique, especially for pancreatic islet transplantation.