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Heat shock proteins and DNA repair mechanisms: an updated overview

Mayra L Sottile1, Silvina B Nadin2

  • 1Tumor Biology Laboratory, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), National Scientific and Technical Research Council (CONICET), Av. Adrián Ruiz Leal s/n Parque Gral. San Martín, 5500, Mendoza, Argentina.

Cell Stress & Chaperones
|September 28, 2017
PubMed

Insights

Heat shock proteins (HSPs) are crucial molecular chaperones involved in protein maintenance and cellular protection. This review explores their role in DNA repair, highlighting their potential as cancer therapy targets.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Background:

  • Heat shock proteins (HSPs), or molecular chaperones, regulate critical cellular functions including protein folding and preventing aggregation.
  • HSPs exhibit cytoprotective effects, primarily through their antiapoptotic activities.
  • The role of HSPs in anticancer drug resistance and their connection to DNA repair mechanisms are areas of significant research interest.

Purpose of the Study:

  • To provide a historical overview of the involvement of HSPs in DNA repair mechanisms.
  • To explore the molecular chaperone capabilities of HSPs in the context of DNA repair.
  • To highlight the potential of HSPs as therapeutic targets in cancer treatment.

Main Methods:

  • Literature review and historical analysis of research on HSPs and DNA repair.
  • Examination of the interactome network between HSPs and DNA repair proteins.
  • Synthesis of findings on HSPs' role in maintaining genome stability.

Main Results:

  • HSPs play a multifaceted role in cellular processes, including protein homeostasis and stress response.
  • Evidence suggests a significant interplay between HSPs and various DNA repair pathways.
  • The interaction network of HSPs with DNA repair proteins is a burgeoning field of study.

Conclusions:

  • HSPs' molecular chaperone functions extend to supporting DNA repair mechanisms.
  • The involvement of HSPs in DNA repair contributes to maintaining genome stability.
  • HSPs represent promising emerging targets for novel cancer therapies due to their roles in DNA repair and drug resistance.
Keywords:
DNA damage responseDNA repairHeat shock proteinsMolecular chaperones

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