Related Experiment Video

Updated: Feb 22, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.2K

The problem of cardio-renal diseases in patients with gout

Claudio Ferri1

  • 1a Division of Internal Medicine and Nephrology, School of Internal Medicine , University of L'Aquila, San Salvatore Hospital Coppito , L'Aquila , Italy.

Current Medical Research and Opinion
|September 28, 2017
PubMed

Insights

High uric acid levels (hyperuricemia) may play a role in heart and kidney disease. Further research is needed to confirm if lowering uric acid benefits cardiovascular and renal health.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Disorders

Background:

  • Mounting evidence suggests a role for hyperuricemia in cardio-renal disease.
  • Uncertainty persists regarding hyperuricemia as a major causal cardiovascular risk factor.
  • Treatment may benefit patients with hyperuricemia accompanying specific conditions like gout, CKD, or cardiovascular risk factors.

Purpose of the Study:

  • To evaluate the evidence for hyperuricemia's role in cardio-renal disease.
  • To determine if lowering uric acid levels is clinically beneficial for cardiovascular and renal health.
  • To explore the potential benefits of reducing serum uric acid in the general population.

Main Methods:

  • Literature analysis to assess existing evidence on hyperuricemia and cardio-renal outcomes.
  • Identification of conditions where hyperuricemia treatment might be beneficial.
  • Review of data supporting clinical trials for uric acid-lowering therapies.

Main Results:

  • Sufficient evidence exists to warrant clinical trials on lowering uric acid levels.
  • Potential benefits of treatment are suggested even without overt gout.
  • Hyperuricemia's association with urate deposition, CKD, and cardiovascular risk factors is noted.

Conclusions:

  • Clinical trials are recommended to ascertain the benefits of reducing uric acid in cardiovascular and renal disease prevention and treatment.
  • Investigating the reduction of serum uric acid levels below 5.0 mg/dL in the general population is practically important.
Abstract

Keywords:
Goutcardiovascular riskhyperuricemiakidney disease

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K

Related Concept Videos

Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.1K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
1.2K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
363
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
758
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
503
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
441