Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

9.6K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
9.6K
RNA Interference01:23

RNA Interference

28.2K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.2K
RNA Structure01:23

RNA Structure

79.3K
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.3K
RNA Structure01:19

RNA Structure

7.8K
The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
7.8K
Experimental RNAi02:15

Experimental RNAi

8.0K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
8.0K
Nucleic Acids02:43

Nucleic Acids

51.1K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
51.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell morphodynamical trajectories enable prediction of gene expression accompanying cell state change.

Cell systems·2026
Same author

Serial Imaging of Tumour and microEnvironment (SITE) platform for live-cell <i>ex vivo</i> modelling of primary and metastatic cancer dynamics.

bioRxiv : the preprint server for biology·2025
Same author

Enhancing RNA Payload and Temperature Stability and Activity with Cationic Peptide-Coated Zinc Oxide Nanoparticles.

ACS pharmacology & translational science·2024
Same author

Evidence of Copper Nanoparticles and Poly I:C Modulating Cas9 Interaction and Cleavage of COR (Conserved Omicron RNA).

Bioengineering (Basel, Switzerland)·2023
Same author

Live-Cell Sender-Receiver Co-cultures for Quantitative Measurement of Paracrine Signaling Dynamics, Gene Expression, and Drug Response.

Methods in molecular biology (Clifton, N.J.)·2023
Same author

Nanoscale Interaction Mechanisms of Antiviral Activity.

ACS pharmacology & translational science·2023

Related Experiment Video

Updated: Feb 22, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.1K

Engineering the RNA-Nanobio Interface.

Vaibhav Murthy1, Robert K Delong2

  • 1Nanotechnology Innovation Center of Kansas State (NICKS), Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, USA. vmurthy@vet.k-state.edu.

Bioengineering (Basel, Switzerland)
|September 28, 2017
PubMed
Summary

RNA nanotechnology enables engineering of RNA-Nanoparticle Complexes (RNA-NPCs) for targeted therapies. Understanding the RNA-nanobio interface is crucial for optimizing RNA-NPC structure, function, and therapeutic activity.

Keywords:
RNA-nanobio interfaceRNA-nanoparticle complexesnano-bio interface

More Related Videos

Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

15.5K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.6K

Related Experiment Videos

Last Updated: Feb 22, 2026

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

15.1K
Nanomanipulation of Single RNA Molecules by Optical Tweezers
06:59

Nanomanipulation of Single RNA Molecules by Optical Tweezers

Published on: August 20, 2014

15.5K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.6K

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • RNA's crucial roles in cellular processes are increasingly understood.
  • This understanding opens opportunities for engineering RNA-Nanoparticle Complexes (RNA-NPCs).
  • RNA-NPCs offer high engineerability through modifications in RNA and nanoparticle chemistry.

Purpose of the Study:

  • To summarize the current state-of-the-art in RNA nanotechnology.
  • To highlight the potential of RNA-NPCs in disease treatment, including cancer.
  • To identify future research directions for RNA-NPC bioengineering.

Main Methods:

  • Review of recent advancements in RNA nanotechnology and RNA-NPC development.
  • Discussion of nanoparticle materials with therapeutic potential (e.g., anticancer).
  • Analysis of RNA design strategies for targeting disease-specific pathways.

Main Results:

  • RNA-NPCs can be engineered with tailored RNA and nanoparticle components.
  • Potential for developing targeted therapies by modifying RNA and NP chemistry.
  • Key challenge identified: understanding the RNA-nanobio interface.

Conclusions:

  • A deeper understanding of the RNA-nanobio interface is essential.
  • This understanding will improve RNA-NPC structure, function, delivery, and activity.
  • Further bioengineering research on RNA-NPCs holds significant promise.