Related Experiment Video
Updated: Feb 22, 2026

High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds
Published on: August 19, 2025
Uncertainty Quantification in Irreversible Electroporation Simulations
1Engineering Science & Mechanics, The Pennsylvania State University, State College, PA 16801, USA. nal5047@psu.edu.
Abstract:
One recent area of cancer research is irreversible electroporation (IRE). Irreversible electroporation is a minimally invasive procedure where needle electrodes are inserted into the body to ablate tumor cells with electricity. The aim of this paper is to investigate how uncertainty in tissue and tumor conductivity propagate into final ablation predictions used for treatment planning. Two dimensional simulations were performed for a circular tumor surrounded by healthy tissue, and electroporated from two monopolar electrodes. The conductivity values were treated as random variables whose distributions were taken from published literature on the average and standard deviation of liver tissue and liver tumors. Three different Monte Carlo setups were simulated each at three different voltages. Average and standard deviation data was reported for a multitude of electrical field properties experienced by the tumor. Plots showing the variability in the electrical field distribution throughout the tumor are also presented.
More Related Videos
08:06Author Spotlight: Optimizing Porous Substrate Electroporation Through Micro and Nanochannels for Enhanced Monitoring and Intermediate Stage Characterization
Published on: September 27, 2024
08:05A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation
Published on: June 8, 2018
Related Concept Videos
Propagation of Uncertainty from Random Error
The Uncertainty Principle
Calculations of Electric Potential II
Consider a...
Electrostatic Boundary Conditions
The surface integral of an electric field is given by Gauss's law in integral form and is related to...
Electrostatic Boundary Conditions in Dielectrics
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's permittivity....
Propagation of Uncertainty from Systematic Error