High-Sensitivity Cardiac Troponin T levels in prehypertensive patients
Lutfu Askin1, Yener Yesiltepe2
1a Department of cardiology , Palandoken State Hospital , Erzurum , Turkey.
Insights
Serum high-sensitivity cardiac troponin T (hs-cTnT) is significantly elevated in prehypertension, a precursor to hypertension. Elevated hs-cTnT levels independently predict prehypertension, aiding in early detection of subclinical myocardial injury.
Area of Science:
- Cardiology
- Biomarkers
- Public Health
Background:
- High-sensitivity cardiac troponin T (hs-cTnT) is a key marker for subclinical myocardial injury.
- Prehypertension, a precursor to hypertension, poses a significant public health challenge.
Purpose of the Study:
- To assess the predictive value of serum hs-cTnT for identifying prehypertension.
- To evaluate hs-cTnT as a potential biomarker for early cardiovascular risk stratification.
Main Methods:
- Prospective study of 100 subjects (50 prehypertensive, 50 normotensive).
- Measurement of serum hs-cTnT levels and comparison between groups.
- Echocardiographic examinations performed on all participants.
Main Results:
- Serum hs-cTnT levels were significantly higher in the prehypertensive group (p < 0.001).
- hs-cTnT demonstrated a positive correlation with prehypertension (r = 0.625, p < 0.001) and was an independent predictor.
- A hs-cTnT cutoff of 0.55 ng/L predicted prehypertension with 86% sensitivity and 60% specificity (AUC = 0.861).
Conclusions:
- Serum hs-cTnT may serve as a valuable biomarker for predicting prehypertension.
- hs-cTnT can complement existing diagnostic tools for early detection of cardiovascular risk.
Background:
High-sensitivity cardiac troponin T (hs-cTNT) is an important non-invasive laboratory-based marker of subclinical myocardial injury. Prehypertension, which may be a precursor of hypertension, is a major public health issue. Our aim was to evaluate the importance of serum hs-cTnT as a marker predicting prehypertension.
Methods:
A total of 100 subjects (45 women and 55 men) consisting of 50 consecutive prehypertensive patients with blood pressures between 120/80 and 139/89 mmHg and 50 normotensive patients with blood pressures < 120/80 mmHg were enrolled prospectively. The hs-cTNT level was calculated and compared between the two groups. Echocardiographic examinations were performed in all patients.
Results:
The hs-cTnT level was significantly higher in the prehypertensive group (p < 0.001) and was positively correlated with prehypertension (r = 0.625, p < 0.001). Hs-cTnT was an independent predictor of prehypertension (odds ratio = 1.043, 95% confidence interval [CI] 1.019-1.067, p < 0.001). An Hs-cTnT level of 0.55 ng/L was predictive of prehypertension with a sensitivity of 86% and specificity of 60% (area under the curve = 0.861; 95% CI, 0.787-0.935; p < 0.001).
Conclusion:
hs-cTnT may complement other diagnostic biomarkers in predicting prehypertension. Abbrevations: high-sensitivity cardiac troponin T, prehypertension, subclinical myocardial injury.
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