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Updated: Feb 22, 2026
12:49
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
3.2K
Afibrinogenemia Acquired by Liver Transplant
Soheila Milani1, Mohsen Aliakbarian, Sakineh Amouian
1From the Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Summary
Liver transplant can transmit fibrinogen deficiency, a rare coagulation disorder, even without a history of inherited conditions. This case underscores the risk of donor-to-recipient disease transmission during transplantation.
Area of Science:
- Transplantation immunology
- Hepatology
- Coagulation disorders
Background:
- Liver transplantation is a critical treatment for end-stage liver disease.
- Potential risks include the transmission of proteins synthesized by the donor liver.
- Fibrinogen deficiency is a rare inherited coagulation disorder with a very low transmission risk via transplant.
Observation:
- A patient without prior inherited coagulation disorders developed fibrinogen disturbance post-liver transplant.
- This suggests a potential transmission event from the donor organ.
Findings:
- The case demonstrates that fibrinogen deficiency can occur in recipients without pre-existing conditions after liver transplantation.
- Standard pre-transplant screening may not fully predict the risk of transmitting such deficiencies.
Implications:
- Highlights the persistent risk of donor-to-recipient disease transmission in liver transplantation.
- Emphasizes challenges in organ procurement, as standard tests may not identify all potential risks.
- Underscores the need for vigilance regarding protein deficiencies post-transplant.
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