Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

753
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
753
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

600
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
600
Measurements of Strain01:27

Measurements of Strain

2.6K
Strain quantifies the deformation of a material under force, typically measured as normal strain, which represents the change in length when compared with the original length. Electrical strain gauges are used for enhanced accuracy. These devices consist of a conductive wire mounted on a paper backing that adheres to the material's surface. These gauges operate on the piezoresistive effect, where the wire's electrical resistance changes in response to mechanical deformation. The strain...
2.6K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

1.8K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.8K
Strain and Elastic Modulus01:15

Strain and Elastic Modulus

9.2K
The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating imidazole propionate and coronary heart disease risk: interplay between histidine intake, fiber, and gut microbiome.

BMC medicine·2026
Same author

Item recognition is associated with gut microbiota composition in healthy humans.

Learning & memory (Cold Spring Harbor, N.Y.)·2026
Same author

Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease.

Annals of neurology·2026
Same author

Prospective longitudinal observational study at an academic medical centre of lifestyle and cognition in older adults with a cochlear implant or hearing aid: study protocol.

BMJ open·2026
Same author

Long-lasting gut microbiome and fecal metabolome alterations after colorectal adenoma removal and their relationship to colorectal cancer.

Cell host & microbe·2026
Same author

Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit.

Immunity·2026

Related Experiment Video

Updated: Feb 22, 2026

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

960

Strains, functions and dynamics in the expanded Human Microbiome Project.

Jason Lloyd-Price1,2, Anup Mahurkar3, Gholamali Rahnavard1,2

  • 1Biostatistics Department, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA.

Nature
|September 28, 2017
PubMed
Summary
This summary is machine-generated.

The Human Microbiome Project

More Related Videos

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
09:31

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

9.7K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.6K

Related Experiment Videos

Last Updated: Feb 22, 2026

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)
09:38

Updated Protocol for the Assembly and Use of the Minibioreactor Array (MBRA)

Published on: September 5, 2025

960
Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging
09:31

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

9.7K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.6K

Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • Characterizing the human microbiome is crucial for understanding health and disease.
  • The National Institutes of Health (NIH) Human Microbiome Project (HMP) has provided extensive data on microbial diversity.
  • A second wave of HMP data offers deeper insights into microbiome personalization.

Purpose of the Study:

  • To present new metagenomic data from the HMP, expanding characterization of the human microbiome.
  • To analyze microbiome personalization using updated computational methods.
  • To investigate microbial and functional diversity across body sites and over time.

Main Methods:

  • Analysis of 1,631 new metagenomes (2,355 total) from 265 individuals across diverse body sites and time points.
  • Application of updated profiling and assembly techniques for enhanced microbiome analysis.
  • Strain identification, body-wide functional profiling, and temporal variation analysis.

Main Results:

  • Subspecies clades were identified as specific to body sites, with some species showing phylogenetic diversity not found in isolate genomes.
  • Microbial pathways were classified into universal, human-enriched, and body site-enriched categories.
  • Microbial variation was decomposed into stable, moderately variable, and rapidly variable subsets over time.

Conclusions:

  • This expanded dataset enhances understanding of baseline human microbial diversity.
  • The study provides new characterizations of personalized microbiome function and dynamics.
  • Findings enable deeper insights into host-microbe interactions and personalized health.