Related Experiment Video
Updated: Feb 22, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
Published on: November 29, 2024
Wound natural healing in treatment of tumor-like hypertrophic scar
Tong Han1, De-Feng Lin1, Hua Jiang1
1Department of Plastic Surgery, Changzheng Hospital, The Second Military Medical University - Shanghai, China.
Background::
Surgical sutures, wound tension, additional skin incisions and other factors may result in recurrence of tumor-like scar.
Objective::
To investigate the role of wound natural healing therapy in tumor-like hypertrophic scar.
Methods::
In this study, tumor-like hypertrophic scars of 47 cases were excised completely and the residual wounds were treated with natural healing. The short-term and long-term effects of treatment were evaluated.
Results::
All cases were successfully cured by natural healing therapy. The healing time of the maximum wound (80mm × 20mm) and the minimal wound (5mm× 5mm) was 25 days and 7 days respectively. The size of new skin scars ranged from 3mm to 11 mm. Clinical followed-up was performed in 34 cases for 36 months. Among them, no recurrence happened in 31 cases and new scar size ranged from 2mm to 8mm, while local recurrence happened in 3 cases whose scar size were less than 5 mm.
Study Limitations::
The cure rate of the therapy was 91.2%.
Conclusion::
The wound natural healing therapy is effective in treating tumor-like hypertrophic scar, which can prevent recurrence and has good cosmetic results.
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