Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adjunctive benzodiazepines in acute schizophrenia.

S Cohen1, A Khan

  • 1University of Washington, Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, Seattle.

Neuropsychobiology
|January 1, 1987
PubMed
Summary

Higher doses of lorazepam equivalents (over 2 mg daily) significantly improved acute exacerbation symptoms in chronic schizophrenia patients within four days. This study explored benzodiazepine augmentation in schizophrenia management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation·2001
Same author

Measurement of CP-violating asymmetries in B0 decays to CP eigenstates.

Physical review letters·2001
Same author

The placebo enigma in antidepressant clinical trials.

Journal of clinical psychopharmacology·2001
Same author

Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

Diabetes·2001
Same author

Hyperglycemia contributes to impaired insulin response in GK rat islets.

Diabetes·2001
Same author

O2 dependence of K+ transport in sickle cells: the effect of different cell populations and the substituted benzaldehyde 12C79.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2001

Area of Science:

  • Psychiatry
  • Clinical Pharmacology
  • Neuroscience

Background:

  • Schizophrenia management often involves neuroleptic medications.
  • Acute exacerbations require effective therapeutic strategies.
  • Adjunctive therapies are explored to enhance treatment efficacy.

Purpose of the Study:

  • To investigate the efficacy of benzodiazepines as adjunctive therapy with neuroleptics.
  • To assess the impact of lorazepam equivalents on acute exacerbation of chronic schizophrenia.

Main Methods:

  • An open clinical trial was conducted on an unlocked ward.
  • Seventeen patients meeting DSM-III criteria for chronic schizophrenia were enrolled.
  • Patient response was monitored using the Brief Psychiatric Rating Scale and Beigel Mania Rating Scale.

Related Experiment Videos

Main Results:

  • Patients receiving >2 mg lorazepam equivalents daily showed greater improvement at 4 days.
  • A dose-dependent response was observed with lorazepam equivalents.
  • Adjunctive benzodiazepine therapy demonstrated potential benefits.

Conclusions:

  • Higher daily doses of lorazepam equivalents (>2 mg) appear beneficial for acute exacerbations of chronic schizophrenia.
  • Benzodiazepines may serve as an effective adjunctive treatment alongside neuroleptics.
  • Further research into optimal dosing and long-term effects is warranted.