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Particulate Matter (Fine Particle) and Urologic Diseases
1Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Ulsan, Korea.
International Neurourology Journal
|September 29, 2017
Summary
Particulate matter (PM) exposure may harm kidney function and increase chronic kidney disease risk. However, current evidence does not link PM to renal cancer, and its association with bladder and prostate cancers remains unclear.
Area of Science:
- Environmental Health
- Nephrology
- Toxicology
Background:
- Particulate matter (PM) is linked to cardiovascular and lung damage via oxidative stress.
- Emerging evidence suggests PM exposure may affect renal function and contribute to chronic urologic diseases.
Purpose of the Study:
- To review PM characteristics associated with renal toxicity.
- To examine recent studies on PM's relationship with urologic diseases and kidney function.
Main Methods:
- Systematic review of studies published since 2008 evaluating PM's renal effects.
- Analysis of research on PM constituents (e.g., lead, cadmium, arsenic, silica) and renal damage.
- Evaluation of studies on PM association with chronic kidney disease, renal cancer, bladder cancer, and prostate cancer.
Main Results:
- Seven studies indicated PM may decrease renal function (estimated glomerular filtration rate).
- Two studies found associations between PM and chronic kidney disease, including immunoglobulin A nephropathy and membranous nephropathy.
- No evidence linked PM to renal cancer; associations with bladder and prostate cancers are inconclusive.
Conclusions:
- PM exposure poses a potential risk to kidney function and may be linked to chronic kidney disease.
- Further research is needed to clarify the causal relationship between PM and specific renal and urologic diseases.
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