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NanoSIMS for biological applications: Current practices and analyses.

Jamie Nuñez1, Ryan Renslow1, John B Cliff1

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High lateral resolution Secondary Ion Mass Spectrometry (SIMS) using NanoSIMS is a powerful tool for biological studies. This review covers NanoSIMS technology, sample prep, analysis, and future impacts in biological research.

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Area of Science:

  • Analytical Chemistry
  • Biological Imaging
  • Materials Science

Background:

  • Secondary Ion Mass Spectrometry (SIMS) is increasingly vital for biological research.
  • High lateral resolution techniques, particularly NanoSIMS, have advanced biological investigations over the last decade.

Purpose of the Study:

  • To provide a comprehensive review of NanoSIMS technology for biological applications.
  • To guide researchers on sample preparation, analysis, data interpretation, and future outlooks.

Main Methods:

  • Overview of SIMS and NanoSIMS instrumentation and development.
  • Discussion of critical experimental factors for NanoSIMS analysis.
  • Presentation of best practices for data analysis and image generation, including colormap selection.

Main Results:

  • Detailed guidance on sample preparation and experimental considerations for NanoSIMS.
  • Introduction of an open-source method for combined secondary electron and ion imaging.
  • Examples of recent biological studies utilizing NanoSIMS.

Conclusions:

  • NanoSIMS is a powerful, high-resolution technique for biological studies.
  • Standardized practices for data analysis and visualization are crucial for NanoSIMS.
  • The technology holds significant promise for future biological discoveries.