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Related Concept Videos

Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

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Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
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Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

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Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
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Peptic Ulcer Disease II: Pathophysiology01:28

Peptic Ulcer Disease II: Pathophysiology

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Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
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Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

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Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Ulcerative colitis associated with pemphigus: a population-based large-scale study.

Khalaf Kridin1, Shira Zelber-Sagi2, Doron Comaneshter3

  • 1a Department of Dermatology , Rambam Health Care Campus , Haifa , Israel.

Scandinavian Journal of Gastroenterology
|September 29, 2017
PubMed
Summary

Pemphigus patients show a higher prevalence of ulcerative colitis (UC). This study found a significant association between pemphigus and UC, suggesting increased risk for UC in individuals with pemphigus.

Keywords:
Pemphigusassociationautoimmunityulcerative colitis

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Area of Science:

  • Dermatology and Gastroenterology
  • Autoimmune Diseases Research
  • Clinical Epidemiology

Background:

  • Pemphigus and ulcerative colitis (UC) are autoimmune conditions with known coexistence.
  • Previous studies have not systematically investigated the association between pemphigus and UC.

Purpose of the Study:

  • To investigate the potential association between pemphigus and ulcerative colitis (UC).
  • To determine if pemphigus increases the risk of developing UC.

Main Methods:

  • A cross-sectional study comparing 1985 pemphigus patients with 9874 matched controls.
  • Prevalence of UC was assessed using Chi-square and t-tests for univariate analysis.
  • Logistic regression model was employed for multivariate analysis of the association.

Main Results:

  • The prevalence of UC was significantly higher in pemphigus patients (0.9%) compared to controls (0.4%).
  • Pemphigus was independently associated with UC (OR 1.9, 95% CI 1.1-3.3, p=0.034).
  • The association was more pronounced in younger patients and remained significant after sensitivity analysis.

Conclusions:

  • Pemphigus is significantly associated with an increased risk of ulcerative colitis.
  • Physicians should consider UC in patients diagnosed with pemphigus.
  • Further research is needed to elucidate the underlying mechanisms of this association.