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Increased RHAMM expression relates to ovarian cancer progression
Stephanie T Buttermore1, Mitchel S Hoffman2, Ambuj Kumar3
1Department of Pathology & Cell Biology, University of South Florida, Morsani College of Medicine, 12901 Bruce B. Downs Blvd., MDC 11, Tampa, FL, 33612, USA.
Journal of Ovarian Research
|September 29, 2017
Summary
Elevated hyaluronan-mediated motility receptor (RHAMM) is found in ovarian cancer (OC) tissues and urine, increasing with disease stage. RHAMM may play a role in OC progression and serve as a prognostic marker.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Elevated hyaluronan-mediated motility receptor (RHAMM) is linked to cancer progression and poor prognosis.
- The specific role of RHAMM in ovarian cancer (OC) remains largely unelucidated.
Purpose of the Study:
- To investigate the role of RHAMM in epithelial ovarian cancer.
- To determine if RHAMM expression correlates with OC characteristics and stage.
Main Methods:
- Western immunoblotting and immunohistochemical staining of clinical OC tissues and cell lysates.
- Enzyme-linked immunosorbent assay (ELISA) for RHAMM detection in urine specimens.
- Correlation analysis of RHAMM levels with OC grade and stage.
Main Results:
- RHAMM expression was significantly elevated in OC tissues, omental metastasis, and urine compared to normal controls.
- RHAMM levels increased with higher OC grade and stage.
- Elevated urinary RHAMM levels decreased post-surgery, indicating tumor origin, and RHAMM was detected at 12x higher levels in OC cell lysates.
Conclusions:
- RHAMM may contribute to ovarian cancer development and progression.
- RHAMM shows potential as a prognostic biomarker for ovarian cancer.
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