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Dysregulation of POPDC1 promotes breast cancer cell migration and proliferation

Johanna Ndamwena Amunjela1, Steven John Tucker2

  • 1School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, U.K.

Bioscience Reports
|September 29, 2017
PubMed

Insights

Popeye domain-containing protein 1 (POPDC1) is suppressed in breast cancer, promoting cell migration and proliferation. Restoring POPDC1 may offer a new therapeutic strategy for breast cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Triple-negative breast cancer lacks targeted therapies due to absent oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2).
  • Suppression of Popeye domain-containing protein 1 (POPDC1) is linked to tumorigenesis and poor outcomes in various cancers.
  • The role of POPDC1 in breast cancer and its therapeutic potential remain underexplored.

Purpose of the Study:

  • To investigate the role of POPDC1 in breast cancer.
  • To assess POPDC1 as a potential therapeutic target for inhibiting breast cancer cell migration and proliferation.

Main Methods:

  • Assessed POPDC1 expression and localization in breast cancer cells.
  • Evaluated the effects of POPDC1 suppression and overexpression on cell migration and proliferation.
  • Investigated the interaction between cAMP and POPDC1.

Main Results:

  • POPDC1 was significantly suppressed and showed reduced cell membrane localization in breast cancer cells.
  • Functional suppression of POPDC1 enhanced breast cancer cell migration and proliferation.
  • POPDC1 overexpression inhibited cell migration and proliferation.
  • cAMP was found to interact with and up-regulate POPDC1 expression.

Conclusions:

  • POPDC1 plays a crucial role in breast tumorigenesis.
  • POPDC1 represents a potential therapeutic target and/or biomarker for breast cancer treatment.
Keywords:
POPDC1breast cancercAMPcell migrationcell proliferation

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