Related Experiment Video
Updated: Feb 22, 2026

A Model of Long-Term Ventricular Fibrillation in Isolated Rat Hearts
Published on: February 17, 2023
A 54-year-old man with new-onset ventricular fibrillation
Kan Liu1, Jamal Ahmed1, David Feiglin1
1Division of Cardiology, State University of New York, Upstate Medical University Hospital, Syracuse, New York, USA.
Clinical Introduction:
A 54-year-old man without significant medical history presented with sudden-onset chest discomfort and multiple episodes of ventricular fibrillation requiring external defibrillation and cardiopulmonary resuscitation. Coronary angiography ruled out significant artery stenosis. Both ventriculography and echocardiography revealed decreased left ventricular ejection fraction (25%). On examination, he was haemodynamically stable. The lungs were clear to auscultation and there was no jugular venous dilation. The cardiac examination revealed a regular rate and rhythm without murmur. Cardiac magnetic resonance (CMR) and 18F-2-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) images were shown (figure 1).heartjnl;103/23/1922/F1F1F1Figure 1Cardiac magnetic resonance with a T1-weighted inversion recovery image (A) and 18F-2-fluoro-2-deoxyglucose positron emission tomography (B) in a 54-year-old man with new-onset ventricular fibrillation.
Question:
Which of the following would be the next best step?Implantable loop recorderElectrophysiological testing for radiofrequency catheter ablationEndomyocardial biopsyGenetic testing.
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