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Androgen replacement therapy for cancer-related symptoms in male advanced cancer patients: study protocol for a

Kouji Izumi1, Kazuyoshi Shigehara1, Takahiro Nohara1

  • 1Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science.

The Journal of Medical Investigation : JMI
|September 29, 2017
PubMed

Insights

Androgen replacement therapy may improve quality of life in advanced cancer patients with hypogonadism. The ARTFORM trial investigated testosterone enanthate

Area of Science:

  • Oncology
  • Endocrinology
  • Clinical Trials

Background:

  • Hypogonadism (low serum androgen levels) is linked to advanced cancer and its symptoms.
  • Testosterone deficiency is common in male cancer patients.

Purpose of the Study:

  • To evaluate the efficacy of androgen replacement therapy (ART) in male advanced cancer patients.
  • To assess the impact of testosterone enanthate on quality of life.

Main Methods:

  • The ARTFORM study is a randomized controlled trial.
  • Male patients with advanced cancer and low testosterone were randomized to receive intramuscular testosterone enanthate or no treatment.
  • Health-related quality of life was measured using validated questionnaires at 12 weeks.

Main Results:

  • The study compared quality of life scores between the treatment and control groups at week 12.
  • Serum total and free testosterone levels were monitored.

Conclusions:

  • The ARTFORM study provides data on the efficacy of androgen replacement therapy in advanced cancer.
  • Results will inform treatment strategies for hypogonadal male cancer patients.
Keywords:
advanced cancerandrogen replacement therapyhealth-related quality of liferandomised controlled trialtestosterone

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